Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate

This is a water-in-oil emulsifier made by joining polyglycerin with isostearic, polyhydroxystearic, and sebacic acids, used in creams, sunscreens, and makeup removers to hold oil and water phases together without added surfactants. It has not had its own dedicated safety review, but CIR has separately reviewed both the polyglyceryl fatty acid ester family and the fatty acids that make it up and found each safe in cosmetic use, which is supportive context rather than a direct finding on this exact molecule.

Cosmetic information for general education, not medical advice. A verdict is a reading of the published evidence, never a guarantee for your skin: any ingredient can irritate someone, so patch test new products and see a professional if you react. Concern is graded on cited evidence, never on hazard-score lists. See how we score.