Multi-Peptide Advanced Serum

The base most products are built on. It carries the other ingredients and has no safety concern.

A corn-derived solvent and humectant that has largely replaced propylene glycol in "clean" formulas; CIR reviewed the alkane diol group and found use concentrations up to about 40 percent in leave-on products like deodorant sticks with no meaningful irritation signal.

A lightweight, odorless emollient made by combining coconut or palm-derived fatty acids with glycerin. It spreads easily, feels non-greasy, and has a long history of use in skin and hair products with no meaningful irritation or sensitization signal.

A stable, saturated version of squalene, a lipid the skin already produces, now usually sourced from olives or sugarcane instead of shark liver. It is very well tolerated across skin types and helps reinforce the skin barrier.

A rich plant butter pressed from shea tree nuts, valued for softening and cushioning dry skin. It is generally well tolerated, though very rare allergic reactions have been reported and people with tree nut allergies who are cautious may want to patch test first.

An emulsifier made from glycerin and stearic acid that stabilizes oil-in-water and water-in-oil formulations. It has a long history of safe use in cosmetics and is assessed as a low-concern ingredient in published safety reviews.

A water or bran extract of rice containing ferulic acid, small peptides and starches. It is a traditional East Asian skincare staple with some supporting antioxidant and mild-brightening data, but most of that evidence comes from cell or animal studies rather than large human trials, so the "brightening" claims on finished products go further than the direct evidence.

A polyol (sugar alcohol) that attracts water to the skin. Like sorbitol and glycerin, it is well tolerated in skincare formulas. It is commonly used to boost hydration without the stickiness of other humectants.

A phospholipid emulsifier from soy or sunflower that binds water and oil and helps other ingredients absorb. It is a natural component of skin membranes, well tolerated, and reviewed as safe as used; a soy-derived grade is not a meaningful concern for a soy food allergy because the protein is largely absent.

A plant-derived antioxidant found in seeds and grains, used in cosmetics to protect against free-radical damage. Published safety assessments grade it low-concern and it is generally well tolerated across skin types.

A hexapeptide designed to reduce facial muscle contractions by interfering with acetylcholine release. Cosmetic-grade formulations show no systemic absorption at recommended use levels and are well tolerated.

An aromatic plant extract rich in natural antioxidants, valued in skincare formulations for its protective properties. Published cosmetic assessments indicate it is generally well tolerated, though the botanical origin means some sensitive individuals may react.

A larger, gentler alpha hydroxy acid than glycolic acid, used to exfoliate and to draw in moisture. It can still cause stinging or increased sun sensitivity at higher concentrations, so daytime SPF use is sensible, but it is generally better tolerated than glycolic acid.

A humectant that draws water into the skin. One of the best-studied, best-tolerated ingredients in personal care.

An antioxidant that helps protect a formula and condition skin. Well tolerated.

A polysaccharide produced by fermentation of fungal cultures, used to thicken and stabilize formulas. It is well tolerated in cosmetics and often chosen by natural-leaning brands. It functions similarly to other gelling agents but comes from a more controlled fermentation source.

A rheology modifier that thickens gels and serums while maintaining a lightweight, non-sticky feel. Provides suspension and stability in water-based formulas. Widely used and well tolerated.

A silicone that gives a smooth, soft feel and helps hold water in the skin. Inert and well studied.

Sodium phytate is a plant-derived chelating agent used to bind trace metals and stabilize formulas, often as a preservative booster alongside other preservatives. Available safety reviews have not identified meaningful irritation or sensitization concerns at typical use levels.

A mineral thickener and anti-caking agent widely used in sunscreens and cosmetics to control texture and prevent ingredient separation. CIR has reviewed silica in cosmetic use and found no basis for concern at the levels used topically.

A fatty alcohol used to soften skin and stabilize creams. Despite the name, it does not dry the skin.

A synthetic surfactant widely used to emulsify oils and water in cosmetics. It is well tolerated and has been used safely in cosmetic formulations for decades.

A strong alkali used in tiny amounts to adjust the pH of cosmetics to safe, skin-friendly levels. At the pH found in finished products, sodium hydroxide is neutralized and well tolerated.

The sodium salt of benzoic acid, used as a preservative in both foods and cosmetics. Decades of safety review support its use at typical cosmetic concentrations, with mild irritation the main reported issue in sensitive skin.

A widely used, gentle preservative also common in food. It is generally well tolerated, though it can occasionally cause mild, transient irritation in people with already-compromised or very reactive skin.

Another sugar-and-fatty-alcohol derived non-ionic surfactant, structurally close to coco-glucoside but made from a shorter (decyl, C10) fatty chain. It is a gentle cleanser generally well tolerated, though a small number of contact-allergy case reports exist, mostly in people with pre-existing skin conditions.

Xanthan gum is a microbial-fermentation-derived polysaccharide used to thicken and stabilize textures, similarly common in food. Cosmetic panel review of this and related microbial gums found them safe as used, with no meaningful irritation signal at typical concentrations.

A more stable, esterified form of vitamin E used as an antioxidant and skin-conditioning ingredient. It is a different substance from the vitamin E acetate implicated in vaping-related lung injury, which involved inhaling the oil, not applying it topically to skin.

Ordinary salt, used in surfactant-based products like shampoos and body washes to adjust viscosity by interacting with the surfactant micelles. It has no meaningful toxicity concern at cosmetic use levels; the main practical downside is that too much can make a formula feel less mild.

Used in tiny amounts to set a product to skin-friendly pH. No concern at those levels.

A widely used preservative, safe at the legal limit of 1% or less. Often the "paraben-free" replacement.