Clarifying Azelaic Acid 20% Cream

The base most products are built on. It carries the other ingredients and has no safety concern.

A naturally occurring dicarboxylic acid used to even tone and calm breakout-prone or redness-prone skin, also available at higher strengths by prescription. It is well tolerated overall, though mild tingling or dryness can occur when starting use.

A corn-derived solvent and humectant that has largely replaced propylene glycol in "clean" formulas; CIR reviewed the alkane diol group and found use concentrations up to about 40 percent in leave-on products like deodorant sticks with no meaningful irritation signal.

A stable, saturated version of squalene, a lipid the skin already produces, now usually sourced from olives or sugarcane instead of shark liver. It is very well tolerated across skin types and helps reinforce the skin barrier.

A silicone that gives a smooth, soft feel and helps hold water in the skin. Inert and well studied.

A humectant that draws water into the skin. One of the best-studied, best-tolerated ingredients in personal care.

A common emulsifier and texture-softener made from glycerin and stearic acid. CIR review of this class found no evidence of reproductive, carcinogenic, sensitizing, or phototoxic effects in the studies examined.

A widely used preservative, safe at the legal limit of 1% or less. Often the "paraben-free" replacement.

A fatty alcohol used to soften skin and stabilize creams. Despite the name, it does not dry the skin.

A more stable, esterified form of vitamin E used as an antioxidant and skin-conditioning ingredient. It is a different substance from the vitamin E acetate implicated in vaping-related lung injury, which involved inhaling the oil, not applying it topically to skin.

A crosslinked acrylic polymer that thickens and stabilizes formulations. Published assessments show it to be well tolerated at cosmetic use levels, with no evidence of penetration into viable skin layers or systemic absorption.

A mild surfactant and emulsifier made from lactic acid and lauric acid. The lactate component makes it less irritating than many other surfactants; generally well tolerated in both rinse-off and leave-on formulas.

A strong alkali used in tiny amounts to adjust the pH of cosmetics to safe, skin-friendly levels. At the pH found in finished products, sodium hydroxide is neutralized and well tolerated.

A lab-made version of a lipid naturally found in the outer skin barrier. It is added to creams and cleansers to help replace lipids that washing can strip away, and it is not linked to irritation or safety concerns.

One of the three major ceramides naturally found in human skin. Ceramide AP plays a critical role in maintaining the skin barrier and is extensively studied as a safe, essential ingredient. It is derived synthetically or from plant sources.

A plant-derived lipid precursor found naturally in skin that supports barrier function and lipid composition. It is used in skincare formulations to strengthen the stratum corneum and is documented as well tolerated, though rare individual sensitivities may occur.

A waxy sterol found naturally in skin and used in cosmetics as an emollient and emulsifier. It supports the skin barrier and is well tolerated across skin types.

Carbomer is a synthetic polymer used purely to thicken and stabilize gels and lotions, with negligible skin penetration due to its large molecular size. Safety reviews have found low toxicity and minimal irritation potential even in leave-on use.

Xanthan gum is a microbial-fermentation-derived polysaccharide used to thicken and stabilize textures, similarly common in food. Cosmetic panel review of this and related microbial gums found them safe as used, with no meaningful irritation signal at typical concentrations.

A key structural lipid naturally found in healthy skin that reinforces the barrier and improves hydration. It is well established in skincare formulations and assessed as having excellent safety across all skin types, including sensitive and compromised barriers.