DermInfusions Fill + Repair Serum with Hyaluronic Acid

The base most products are built on. It carries the other ingredients and has no safety concern.

A humectant that draws water into the skin. One of the best-studied, best-tolerated ingredients in personal care.

A form of vitamin B3 used to support a more even-looking tone and a comfortable barrier. Well tolerated at cosmetic levels.

A lightweight humectant and solvent similar in role to propylene glycol, used to carry actives and give lotions a lighter feel. CIR has reviewed it and considers it safe as used in cosmetics.

A natural osmolyte produced by halophilic bacteria. Used for hydration and protective stress response, ectoin is well tolerated with emerging evidence for skin barrier support and soothing. No safety concerns flagged in cosmetic applications.

A humectant that holds water at the skin surface for a more hydrated look. No safety concern.

A lower molecular weight version of hyaluronic acid designed for better skin penetration. It has been extensively studied and shown to support skin hydration and barrier function with excellent tolerability in diverse formulations and skin types.

A chemically modified form of hyaluronic acid that improves stability and penetration in skincare formulations. Clinical assessments show it hydrates skin effectively and is well tolerated across sensitive and normal skin types.

A chemically cross-linked form of sodium hyaluronate designed to remain on the skin surface longer and provide sustained hydration. It functions as a humectant and is well tolerated, with the same safety profile as standard hyaluronic acid.

A hexapeptide designed to reduce facial muscle contractions by interfering with acetylcholine release. Cosmetic-grade formulations show no systemic absorption at recommended use levels and are well tolerated.

A signal peptide attached to palmitic acid that activates collagen synthesis in skin cells. Well tolerated across skin types with no significant safety concerns in cosmetic use.

A peptide lipid that mimics collagen fragments and signals skin cells to increase collagen production while reducing inflammation. Established in anti-aging formulas with a consistent safety record.

A synthetic peptide sequence derived from or mimicking Epidermal Growth Factor, designed to support skin renewal and healing. Cosmetic-grade formulations show no systemic absorption at recommended levels and are well tolerated in topical use.

A naturally derived humectant made from fermented plant sugars that draws water into the skin. It is well tolerated in cosmetics and is used to support hydration and skin softness.

Green tea extract is a well-studied topical antioxidant with a long history of use in serums and moisturizers, generally well tolerated at cosmetic concentrations. Panel safety reviews of Camellia sinensis-derived ingredients have not identified meaningful topical hazard.

A plant extract long used in traditional wound care and now common in "cica" soothing products, valued for calming redness and supporting the skin barrier. It is generally well tolerated, with rare contact allergy reported.

A plant-derived compound (from babchi seed) marketed as a gentler alternative to retinol, with some small clinical studies showing similar skin-texture benefits and less irritation. Evidence is still limited compared to retinoids, and formal safety review data are less extensive than for long-established ingredients.

A lab-made version of a lipid naturally found in the outer skin barrier. It is added to creams and cleansers to help replace lipids that washing can strip away, and it is not linked to irritation or safety concerns.

One of the three major ceramides naturally found in human skin. Ceramide AP plays a critical role in maintaining the skin barrier and is extensively studied as a safe, essential ingredient. It is derived synthetically or from plant sources.

A key structural lipid naturally found in healthy skin that reinforces the barrier and improves hydration. It is well established in skincare formulations and assessed as having excellent safety across all skin types, including sensitive and compromised barriers.

Natural fat molecules present in healthy skin that help reinforce the skin barrier. They are graded with no known concerns in cosmetic assessments and are well tolerated as skin conditioning agents.

A plant-derived lipid precursor found naturally in skin that supports barrier function and lipid composition. It is used in skincare formulations to strengthen the stratum corneum and is documented as well tolerated, though rare individual sensitivities may occur.

Finely milled oat that the FDA recognizes as an over-the-counter skin protectant for temporary relief of minor itching and dryness. Well tolerated, including on eczema-prone skin, with rare contact allergy in people with pre-existing oat or cereal sensitivity.

Bisabolol is a botanically derived (or synthetically nature-identical) compound used for its calming, anti-irritant reputation in sensitive-skin formulas. Safety reviews and long clinical use have found it well tolerated with a low rate of reported reactions.

A fruit extract from the Australian Kakadu plum, notable for high vitamin C and polyphenol content, used in cosmetics for antioxidant claims. Topical safety data is limited, but the fruit has a long traditional use history and no documented safety signals have emerged in published literature at cosmetic concentrations.

Sodium PCA is a natural component of skin's own moisturizing factor and is used in cosmetics as a humectant to help skin hold onto water. It has an extensive history of safe use with no meaningful irritation or sensitization signal.

A naturally occurring tripeptide (amino acid compound) that functions as a cellular antioxidant. It is graded low concern in cosmetic assessments, though absorption across intact skin appears limited.

A stable, saturated version of squalene, a lipid the skin already produces, now usually sourced from olives or sugarcane instead of shark liver. It is very well tolerated across skin types and helps reinforce the skin barrier.

A natural alkaloid and studied active ingredient in skincare, valued for its antioxidant properties and potential to promote local circulation and reduce puffiness. Topical application results in minimal systemic absorption, graded low concern in regulatory assessments.

A soothing humectant that helps skin and hair look conditioned. Very well tolerated.

A rich plant butter pressed from shea tree nuts, valued for softening and cushioning dry skin. It is generally well tolerated, though very rare allergic reactions have been reported and people with tree nut allergies who are cautious may want to patch test first.

A plant-derived water or extract used mainly as a soothing humectant filler. Evidence for dramatic skin benefits beyond mild hydration and soothing is limited, but it is well tolerated by most people.

A probiotic-derived ferment lysate containing amino acids and polysaccharides. Limited published research suggests it may benefit skin hydration, though the cosmetic evidence base is smaller than for established ingredients.

Chamomile extract is used for its soothing and mild antioxidant reputation and is generally well tolerated. It belongs to the Asteraceae (Compositae) plant family, so people with a known ragweed or daisy-family allergy occasionally react to it and may want to patch test first.

The smallest and most penetrating alpha hydroxy acid, used to loosen the bonds between dead skin cells for smoother texture and tone. It is a genuine irritant at higher concentrations or low pH, can increase sun sensitivity, and the EU restricts free acid content and requires sunscreen-use wording on labeling.

Mandelic acid is a larger-molecule alpha hydroxy acid that tends to penetrate skin more slowly than glycolic acid, which is generally associated with less stinging and redness. It carries the same general AHA cautions around sun sensitivity but is often better tolerated by reactive skin.

A glycerin derivative used as a skin conditioner and preservative booster, often paired with phenoxyethanol to allow lower total preservative levels. It has a low irritation and sensitization profile in safety reviews.

A mild non-ionic cleansing agent made from coconut fatty alcohols and plant sugars (glucose). It is widely used in sulfate-free shampoos and gentle cleansers and is one of the least irritating surfactants in common use.

A sugar-derived, biodegradable cleansing surfactant made from coconut/palm fatty alcohol and glucose; it is markedly gentler than sulfates and is the workhorse of "sensitive skin" or fragrance-free cleansers. CIR reviewed it with other alkyl glucosides and found it safe as used when the finished product is formulated to be non-irritating.

Another sugar-and-fatty-alcohol derived non-ionic surfactant, structurally close to coco-glucoside but made from a shorter (decyl, C10) fatty chain. It is a gentle cleanser generally well tolerated, though a small number of contact-allergy case reports exist, mostly in people with pre-existing skin conditions.

A mild plant-derived emulsifier combining polyglycerol and lauric acid. Used in gentle formulas to blend oil and water phases; well tolerated across skin types at cosmetic concentrations.

A synthetic ester used to provide lightweight emollient and conditioning properties in cosmetic formulations. Limited but consistent use history in cosmetics without adverse reports.

A silicone that gives a smooth, soft feel and helps hold water in the skin. Inert and well studied.

Pentylene glycol is a humectant and solvent that also offers mild antimicrobial support in formulas. It is generally well tolerated, with only rare reports of irritation, mostly in already sensitive or compromised skin.

A mild surfactant and emulsifier made from lactic acid and lauric acid. The lactate component makes it less irritating than many other surfactants; generally well tolerated in both rinse-off and leave-on formulas.

A synthetic film-forming polymer derived from vinyl compounds, commonly used to provide hold and texture in skincare and cosmetics. It is generally well tolerated and does not bioaccumulate in skin or tissue.

Xanthan gum is a microbial-fermentation-derived polysaccharide used to thicken and stabilize textures, similarly common in food. Cosmetic panel review of this and related microbial gums found them safe as used, with no meaningful irritation signal at typical concentrations.

Used like sodium hydroxide to adjust pH in cosmetics at very low levels. At finished-product pH, it is neutralized and well tolerated.

A widely used emulsifier and solubilizer that has been in cosmetics and pharmaceuticals for decades. The CIR has assessed it as safe with no known concerns at typical cosmetic concentrations. As with any surfactant, some people with very sensitive skin may experience mild irritation.

A crosslinked silicone polymer that creates a velvety texture in primers and powders. The crosslinked structure does not change its safety profile, and it is inert and well tolerated.

Carbomer is a synthetic polymer used purely to thicken and stabilize gels and lotions, with negligible skin penetration due to its large molecular size. Safety reviews have found low toxicity and minimal irritation potential even in leave-on use.

A waxy sterol found naturally in skin and used in cosmetics as an emollient and emulsifier. It supports the skin barrier and is well tolerated across skin types.

A film-forming copolymer used to add texture and stability to formulas. Well-tolerated with no documented safety concerns at cosmetic concentrations.

A fermented extract of radish root that acts as a natural preservative and skin-conditioning agent. It has shown antimicrobial properties in formulation work and is well tolerated in rinse-off and leave-on products, though individual sensitivities can vary.

A salt derived from citric acid that buffers pH and prevents metal oxidation in formulas. Widely used in food and cosmetics, it is well tolerated at cosmetic concentrations.

Used in tiny amounts to set a product to skin-friendly pH. No concern at those levels.

Gluconolactone is a polyhydroxy acid that exfoliates gently while also acting as a humectant and mild antioxidant, and it is generally recommended for sensitive or barrier-compromised skin over smaller AHAs. A full cosmetic panel review found it safe as used, though some users still report mild stinging or redness at higher concentrations.

An amino acid-derived chelating agent that stabilizes formulas by binding trace metals. Published assessments support its use at cosmetic concentrations.

A lightweight, odorless emollient made by combining coconut or palm-derived fatty acids with glycerin. It spreads easily, feels non-greasy, and has a long history of use in skin and hair products with no meaningful irritation or sensitization signal.

Lavender essential oil naturally contains linalool, geraniol, and coumarin, several of the recognized fragrance allergen constituents, so it can trigger contact reactions in fragrance-sensitive users even though it is a "natural" ingredient. It is not a general hazard for most people, but those with a known fragrance allergy should treat it like any other essential oil.

A volatile ketone used as a fragrance component that occurs naturally in raspberries. Dermatological testing in cosmetics is limited, though it is recognized as safe by regulatory bodies when used in fragrance applications. Fragrance components can trigger reactions in sensitive individuals.

A widely used preservative, safe at the legal limit of 1% or less. Often the "paraben-free" replacement.

A widely used, gentle preservative also common in food. It is generally well tolerated, though it can occasionally cause mild, transient irritation in people with already-compromised or very reactive skin.